CD Laboratory for Activation of Immunogenic Cell Death in Lung Cancer

Analysis of CRISPR-edited lung cancer cells: Modern genome editing approaches in vitro and in vivo enable targeted investigation of immunogenic cell death.

Cancer cells can be eliminated by the body‘s own immune system, supported by so-called immunotherapies or chemo-immunotherapies, and in many patients, tumours can be controlled in the long term. However, non-small cell lung cancer (NSCLC) remains extremely difficult to treat because it is highly effective at evading this immune defence. This often leads to relapses within months or a few years.

The CD laboratory for “Activation of immunogenic cell death lung cancer” (or ARNICA = Activating Regulated Necrosis In CAncer) investigates therapeutic strategies aimed at making the cancer cells more visible for the immune system, and seeks to identify biomarkers as well as treatment strategies that support this process.

Cultivation and analysis of lung cancer cells

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